In people stabilized on fairly large doses of lithium, short-phrase oral metronidazole therapy is associated with elevation of serum lithium amounts and, in some instances, signs of lithium toxicity.
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Use of cimetidine with oral metronidazole may possibly prolong the 50 %-lifestyle and decrease plasma clearance of metronidazole.
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METROGEL-VAGINAL affords minimum peak serum amounts and systemic exposure (AUCs) of metronidazole in comparison with 500 mg oral metro‑nidazole dosing. Although these reduced levels of exposure are less likely to supply the typical reactions found with oral metronidazole, the potential of these and various reactions can't be excluded presently.
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